Despite your best efforts (and your hard-earned money), you may not be able to achieve optimal detoxification. All the money you spend on your health and all your best efforts might not be benefitting you as much as you think. Why? You might have a genetic mutation on your MethyleneTetraHydroFolate Reductase enzyme. MTHFR.
MTHFR Genetic mutations are common
Heterozygous = 1 copy of the gene from either parent
Homozygous = 1 copy of the gene from each parent
Below is a summary of the frequency of a MTHFR mutation in a mixed population and the effect of the mutation on methylation capacity:
|MTHFR C677T||MTHFR A1298C|
|Normal (no mutation) C677T||Normal (no mutation) A1298C|
|Frequency: 44%||Frequency: 46%|
|Methylation Capacity: Not Impaired||Methylation Capacity: Not Impaired|
|Heterozygous C677T||Heterozygous A1298C|
|Frequency: 41%||Frequency: 41%|
|Methylation Capacity:40% loss of function||Methylation Capacity: 20% loss of function|
|Homozygous C677T||Homozygous A1298C|
|Frequency: 15%||Frequency: 13%|
|Methylation Capacity:70% loss of function||Methylation Capacity: 40% loss of function|
Cellular biologyEvery cell of our body (all 50 trillion of them!) works to optimize health by changing toxins into less toxic particles. As an example, one of the ways it does this is by adding methyl groups (CH3) to heavy metals, making them water soluble and we then excrete them through urination. Adding methyl groups to detoxify and protect us is called methylation and this is the goal of our body in how it wants to protect us and keep us healthy.
- Repairs and regenerates your cells, tissues and DNA
- Regulates gene expression and protein function
- Synthesizes neurotransmitters that influence mood, sleep, behavior, cognition, and memory
- Controls homocysteine; keeps inflammation in check
- Aids liver in processing fats
- Activates and modulates the immune system
- Modifies toxins and heavy metals
Methylation is so critical to overall health. Here are just a few things that the CH3 groups do for us:
|Abnormal methylation in…||Is associated with…|
|Endothelium (cells that line blood vessels)||Cardiovascular disease, atherosclerosis|
|White Blood Cells||Excessive blood clotting, stroke|
First things firstMethylation can be optimized but first, find out if you have a MTHFR mutation. Below is a list of resources and tests you can use to determine methylation defects that you may have:
If you have a mutation, what happens next?Again, your practitioner will be your best and most-trusted resource. But you can supplement with methyl folate and methylated B12 to help your detoxification pathway. It’s important to know what type of mutation you have and then what to do about it.
Interesting Coincidence?An established client came in for her full body scan and had been diagnosed with the MTHFR A1298C mutation and started on the supplements specific to her condition. She was concerned that she would have lots of inflammation due to this new diagnosis.
This client noted the following since starting on her new supplement regime she has been on for about 2 years:
- Decrease in bilateral breast tenderness
- Able to eat most anything without experiencing flu-like symptoms for several days afterwards / improved digestion
- Significantly decreased sinus congestion and allergies
- Overall feeling of well-being
Realize, thermography cannot diagnose any condition, but often improvement in the ability to detoxify the body can be seen in comparative scans with reduction in inflammation.
SummaryWe spend lots of money and time working to optimize health. With thermal imaging, we watch for changes over time as an early indication of changes in health. Both Lynda and I have noticed an increase in the number of our clients, both established and new, that come into our clinics with a diagnosis of MTHFR mutation. Many of these clients are finally finding answers to their struggles and we encourage all of our clients to explore this avenue for themselves.
The methylation cycle is complex and this newsletter is not meant to give a complete understanding of its importance. MTHFR mutations effect your detoxification system as well as neurotransmitter production. We may discuss this further in a future newsletter and share our experience with our own familial MTHFR mutation in one of our family member. Please let us know what you think and as always, share this information with your loved ones.
Yours in health,
Brenda and Lynda Witt
P.S. For those interested, Brenda is heterozygous for C677T mutation; no A1298C mutation.